A chryseobacterium meningosepticum outbreak observed in 3 clusters involving both neonatal and nonneonatal pediatric patients. Elizabethkingia meningoseptica, previously known as chryseobacterium meningosepticum, is widely distributed in soil and water including municipal water. Chryseobacterium meningosepticum, formerly known as flavobacterium meningosepticum or cdciia, is a nonfermentative, nonmotile, oxidasepositive gramnegative rod that is widely distributed in nature. Successful control of elizabethkingia meningoseptica outbreak. Although she received intravenous antibiotics with good in vitro activity against the organism, the. Chryseobacterium flavobacterium meningosepticum a betalactam buster. Elizabethkingia meningosepticum nursing ceu ceufast. The chryseobacterium species are inhabitants of soil and water. The patient received vancomycin therapy for 21 days and was discharged in a state of complete recovery. A chryseobacterium meningosepticum colonization outbreak in a. Chryseobacterium flavobacterium meningosepticum a beta.
First isolation and characterization of chryseobacterium. Chryseobacterium indologenes in a woman with acute. We report two cases of sepsis in critically ill patients in two tertiary care hospitals in recifepe, brazil. It is ubiquitously found in soil and water and it has also. Pdf bacteremia due to elizabethkingia meningoseptica. Chryseobacterium meningosepticum is a ubiquitous gramnegative bacillus historically associated primarily with meningitis in neonates and a wide variety of infections in immunocompromised patients. Clinical infection caused by c meningosepticum is very rare among healthy adults. Bruun and ursing, 1987, in contrast members of all chryseobacterium species produce a yellow to orange nondiffusible flexirubin type pigment. The taxonomic positions of six strains including the type strain of chryseobacterium meningosepticum king 1959 vandamme et al. Ceftizoxime is a newer third generation cephalosporin and flavobacferium been used in the therapy of gram positive menibgosepticum negative meningitis sunset appearance of eyes was present. Elizabethkingia meningoseptica is a nonfermentative gramnegative bacillus that is ubiquitously found in hospital environments and as such, it has been associated with various nosocomial infections. Limited data are available on chryseobacterium spp. Sep 01, 2000 this is the first report of a cluster of atypically variant strains of c. Chryseobacterium indologenes infection in a newborn.
Chryseobacterium meningosepticum as a cause of cellulitis. Chryseobacterium gleum infection in patient with extreme. Yellowpigmented, gramnegative organisms isolated from raw chicken were investigated by means of a polyphasic taxonomic approach and were shown to represent a novel species in the genus chryseobacterium, for which the name chryseobacterium vrystaatense sp. Introduction we report the seventh case of chryseobacterium indologenes occurring in the united states of america. Chryseobacterium meningosepticum bacteremia in diabetic. Elizabethkingia meningoseptica is a gramnegative, rodshaped bacterium widely distributed in nature e. We present the case of a patient with endstage renal disease who developed purulent pericarditis with c. Chryseobacterium is a genus of gramnegative bacteria. Waterborne elizabethkingia meningoseptica in adult. Patients and methods from april to october 2002, a strain. Clinical and epidemiological features of chryseobacterium. In vitro antibiotic synergy against flavobacterium.
Apr 12, 2016 we report for the first time a case of community acquired chryseobacterium indologenes soft tissue infection in an immunocompetent patient. Identification and epidemiological relatedness of clinical. The genus contains more than 100 described species from diverse habitats, including freshwater sources, soil, marine. Chryseobacterium respiratory tract infections in patients. Chryseobacterium and elizabethkingia species may be long, thin, slightly curved, and occasionally filamentous on gram stain. Host factors are the major determinants of the outcomes of c. This work describes cloning of the gene encoding that enzyme from c. Chryseobacterium form typical yelloworange color colonies due to flexirubintype pigment.
It is widely distributed in the environment, yet also an acknowledged opportunistic human pathogen. Chryseobacterium flavobacterium meningosepticum, an organism resistant to multiple antibiotics, is an occassional cause of infection in immunocompromised adults and in neonates, in whom it most commonly causes meningitis. Fifty isolates 24 chryseobacterium meningosepticum, 20 chryseobacterium indologenes, two chryseobacterium gleum, and 4 chryseobacterium spp. Susceptibilities of chryseobacterium indologenes and. The pathogen causes meningitis in premature and newborn infants and pneumonia, endocarditis, postoperative bacteremia, and meningitis usually associated with severe underlying illness in adults 47. Elizabethkingia meningoseptica strains either are not pigmented or produce a weak yellow nondiffusible pigment e. Flavobacterium meningosepticum, cdc group iia bacteriology a bacterium of soil, water, plants, foods, hospital waterincubators, tap water, hemodialysis systems, pharmaceuticals mode of transmission uncertain, but probably linked to contaminated medical devices and fluids. King at the communicable disease center now the centers for disease control and prevention in 1959.
In the hospital she was provided with the intravascular catheter, urinary catheter and endotracheal tubus and was on mechanical ventilation for 18 days. Chryseobacterium infection may present with a variety. Pdf a chryseobacterium meningosepticum outbreak observed. Apr 24, 2020 this is the first report of a cluster of atypically variant strains of c meningosepticum, which may be an emerging pathogen in newborns and the immunocompromised. Phylogenetic insights into the diversity of chryseobacterium. Members the genus chryseobacterium are widely distributed microorganisms that can be recovered from a wide variety of environments, such as fresh water, sewage and wastewater, soil or food sources, such as milk, poultry and meat and dairy products. Atypical chryseobacterium meningosepticum and meningitis and. This pdf is available for free download from a site hosted by medknow publications. In the hospital environment, they exist in water systems and wet. Chryseobacterium meningosepticum is a lactosenonfermenting gramnegative bacilli ubiquitously found in the natural and hospital environment.
The pathogen causes meningitis in premature and newborn infants and pneumonia, endocarditis, postoperative bacteremia, and meningitis usually associated with severe underlying illness in. This course will focus on one species of elizabethkingia, namely elizabethkingia meningosepticum. Chryseobacterium meningosepticum is rarely encountered as a pathogen causing peritonitis in adults. As an agent of neonatal meningitis, it reportedly demonstrates mortality rates of up to 57% and produces severe postinfection sequelae including hydrocephalus, deafness, and developmental delay. Chryseobacterium meningosepticum is an aerobic gramnegative rod widely distributed in natural environments.
From 1996 to 1999, 17 culturedocumented systemic infections due to novel, atypical strains of chryseobacterium meningosepticum occurred in two newborns and 15 immunocompromised patients in a medical center in taiwan. Jan 14, 2011 chryseobacterium indologenes is an uncommon human pathogen. Pdf chryseobacterium meningosepticum bacteremia in diabetic. We report on the case history of a 17yearold boy with thalassemia major and meningitis and sepsis caused by c. Chryseobacterium meningosepticum and flavobacterium. There have been an increasing number of infections in fish associated with different species of chryseobacterium, being considered potentially emerging pathogens. Antimicrobial susceptibility and epidemiology of a. Urinary tract infection by chryseobacterium indologenes. We present the case of a patient with endstage renal disease who developed purulent pericarditis with c meningosepticum infection, which rapidly evolved into cardiac. Aug 16, 2009 to report the epidemiologic, bacteriologic, and clinical features of a chryseobacterium meningosepticum outbreak in a neonatal intensive care unit nicu of a referral teaching hospital. Patients and methods from april to october 2002, a strain of c. The genbankemblddbj accession numbers for the 16s rrna gene sequences of elizabethkingia meningoseptica atcc 253t and.
Chryseobacterium meningosepticum is a ubiquitous gramnegative bacillus historically associated primarily with meningitis in neonates and a wide variety of. This is the first report of a cluster of atypically variant strains of c meningosepticum, which may be an emerging pathogen in newborns and the immunocompromised. A limited range of antibiotic classes are available for treatment of chryseobacterium meningosepticum infections. If you do not see its contents the file may be temporarily unavailable at the journal website or you do not have a pdf plugin installed and enabled in your browser. Pdf elizabethkingia meningosepticum chryseobacterium. Elizabethkingia meningoseptica, previously known as chryseobacterium meningosepticum, 1 is widely distributed in soil and water including municipal water supplies with chlorination. With 215 c indologenes isolates between january 1, 2004 and september 30, 2011, at a medical center, we analyzed the relationship between the prevalence of c indologenes infections and total prescription of colistin and tigecycline, clinical manifestation, antibiotic susceptibility, and outcomes. Elizabethkingia species were first described by elizabeth o. Fifty isolates 24 chryseobacterium meningosepticum, 20 chryseobacterium indologenes, two chryseobacterium gleum, and 4. Chryseobacterium meningosepticum and chryseobacterium. Lin and colleagues describe 9 adults 4082 years of age and 2 children 0. We report a rare case of urinary tract infection by chryseobacterium indologenes in a young girl, operated for renal calculus and successfully treated with piperacillintazobactam combination.
Waterborne elizabethkingia meningoseptica in adult critical. Chryseobacterium meningosepticum infection and cardiac. Both organisms grow well and form colonies within 24. Chryseobacterium meningosepticum is a ubiquitous gramnegative bacillus historically associated with meningitis in premature neonates. Chryseobacterium meningosepticum journal of clinical microbiology.
Unforeseeable presentation of chryseobacterium indologenes. A case of healthcare associated pneumonia caused by. During a period of eleven weeks two patients presented with septicaemia and. A chryseobacterium meningosepticum colonization outbreak in a neonatal intensive care unit.
Jun 22, 2015 in this report we have presented a patient with extreme malnutrition and a hepatic lesion. Pdf chryseobacterium meningosepticum as a cause of. A read is counted each time someone views a publication summary such as the title, abstract, and list of authors, clicks on a figure, or views or downloads the fulltext. Sentry program during the 5year period 1997 to 2001 revealed that chryseobacterium species constitute only 0. Most infections have been detected in hospitalized patients with severe underlying diseases who had indwelling devices implanted. At the time of writing january 2019, the list of prokaryotic names with standing in nomenclature. In summary, cefepime was more active than cefpirome against the c. Most frequently associated with neonatal meningitis 3,4, the organism also has been described in osteomyelitis. Oct 01, 2004 host factors are the major determinants of the outcomes of c. Unlike many bacteria, it produces a phosphateirrepressible periplasmic alkaline phosphatase ap. Elizabethkingia meningosepticum chryseobacterium meningosepticum infections in children article pdf available in international journal of pediatrics 201.
All clinical isolates, which were initially misidentified as aeromonas salmonicida by an automated bacterial identification. Transfer of chryseobacterium meningosepticum and chryseobacterium miricola to elizabethkingia gen. Most frequently associated with neonatal meningitis 3,4, the organism also has been described in. They can be found in freshwater, saltwater, and soil 106, 110, 119. Alternatively, you can download the file locally and open with any standalone pdf reader. Chryseobacterium meningosepticum sepsis complicated with. He was successfully treated with vancomycin and ceftazidime for three weeks with good clinical outcome. The crystal structure of the classb betalactamase, blab, from the pathogenic bacterium, chryseobacterium meningosepticum, in complex with the inhibitor, dcaptopril, has been solved at 1. Chryseobacterium meningosepticum is a rare pathogen in cases of bacterial meningitis in adults and adolescents. Chryseobacterium meningosepticum bloodstream infections in 11 nonneonatal patients were reported.
Chryseobacterium indologenes is an uncommon human pathogen. Author links open overlay panel antonietta lambiase a mariassunta del pezzo a. A chryseobacterium meningosepticum colonization outbreak. Of these species, chryseobacterium meningosepticum is the most. Chryseobacterium species are chemoorganotrophic, rod shape gramnegative bacteria. In the hospital environment, they exist in water systems and wet surfaces. Nevertheless the knowledge of the diversity of species associated with fish disease is partial due to the problems for a correct identification at the species level based exclusively on phenotypic laboratory methods. Elizabethkingia meningoseptica, previously known as chryseobacterium meningosepticum, is a gramnegative bacillus that is widely distributed in nature.
The progressive improvement in laboratory studies is shown in table. Flavobacterium meningosepticum from neonatal meningitis. Both cefepime and cefpirome had poor activity against c. The genus contains more than 100 described species from diverse habitats, including freshwater sources, soil, marine fish, and human hosts. Although there were a mere 18 species of chryseobacterium in 2006 5, that number had risen to 58 by 2014 6. Chryseobacterium meningosepticum is a gramnegative rod with a worldwide distribution. We report here a case of chryseobacterium meningosepticum bacteremia in a diabetic nephropathy patient on hemodialysis. Chrysobacterium meningosepticum 20041001 ahc media. Formerly flavobacterium indologenes, chryserobacterium indologenes is a yellow pigmented, gramnegative filamentous, nonmotile rod and can be found in soil, plants, foodstuffs and water sources including those found in hospitals 1234. Lower respiratory tract 52% and blood 46% were the major sites. The genus was previously classified as flavobacterium and then reclassified in 1994 as chryseobacterium before receiving its current taxonomic designation in 2005. Elizabethkingia, chryseobacterium and myroides species.
Chryseobacterium meningosepticum is the most pathogenic member of the genus. Implications for therapeutic options clinical infectious diseases, may 1998 m. A 54yearold woman who underwent continuous ambulatory peritoneal dialysis for 8 years developed peritonitis due to c. For reasons that are explained in the section phylogeny, the splitting of the genus chryseobacterium was proposed very recently kim et al. All neonates were colonized in the endotracheal tubes and respiratory secretions, but none of them. Endocarditis due to chryseobacterium meningosepticum bomb k. Chryseobacterium indologenes an overview sciencedirect. This report documents a rare case of chryseobacterium indologenes urinary tract infection in senegal. Aug 02, 2019 flavobacterium meningosepticum from neonatal meningitis. An outbreak of nosocomial infections by flavobacterium meningosepticum in a neonatal intensive care unit is described. Kwang kyu kim 1, myung kyum kim 1, ju hyoung lim 1, hye yoon park 1, sungtaik lee 1. Some species of chryseobacterium have been involved in human infections, acting as sporadic but severe opportunistic nosocomial pathogens. The genera chryseobacterium and elizabethkingia springerlink. Elizabethkingia meningoseptica international journal of infection.
Atypical chryseobacterium meningosepticum and meningitis. We present a case of ventilatorassociated pneumonia caused by c. Endocarditis due to chryseobacterium meningosepticum k bomb 1, a arora 1, n trehan 2 1 departments of microbiology, escorts heart institute and research centre, okhla road, new delhi 110 025, india 2 departments of cardiothoracic surgery, escorts heart institute and research centre, okhla road, new delhi 110 025, india. Elizabethkingia are opportunistic pathogens preferentially causing illness among neonates and, usually, immune compromised individuals with underlying medical conditions. Bacteremia due to elizabethkingia meningoseptica sciencedirect. Clinical and microbiological analysis of bloodstream infections caused by chryseobacterium meningosepticum in nonneonatal patients. Chryseobacterium meningosepticum as a cause of cellulitis and sepsis in an immunocompetent patient article pdf available in journal of medical microbiology 56pt 8. Chryseobacterium indologenes is an uncommon human pathogen reported in hospital outbreaks in taiwan and there have been some sporadic cases reported in europe and in the usa mainly from immunesuppressed patients. Chryseobacterium respiratory tract infections in patients with cystic fibrosis.
61 903 872 622 297 724 1202 262 1511 553 748 463 236 434 527 946 514 964 1374 1030 815 1197 169 1366 904 1145 672 629 1282 23 414 995 956 400 1287